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Traceless Linkers

A traceless linker is a type of linker which leaves no residue on the compound after cleavage, i.e. it is replaced by hydrogen [7].

''Traceless linking'' is regarded as ''leaving no functionality'' which, for arenes and alkanes, means that only a C-H bond remains at the original position of attachment (Scheme 6.1.32) (for reviews see Ref. [113]). This anchoring mode plays an important role in the design and synthesis of drug-like molecules, because the absence of any remaining part of the linker leads to an unbiased library.

Cleavage

Scheme 6.1.32. Principle of the traceless linker.

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