Dmf

Dde [76]

Primary amines

REM linker (86) Dde linker (87)

Fig. 6.1.7. The REM and the Dde linkers.

Tab. 6.1.5. Some reducing agents used for detachment.

Reducing agent

Solvent

Suitable linker

Product nBu3 SnH

NaBH4

LiBH4

Na/Hg

Phosphines

Toluene THF/H2O THF MeOH

Selenium linker Amide Thioester Sulfone linker Disulfide linker

Hydrocarbons Alcohols [80] Alcohols Alkanes Thiols [81-84]

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