Generation and release of polymer-supported reactive intermediates or activated reactants have been demonstrated as a powerful concept leading to several novel

advanced polymer reagents for important transformations. The reagents are capable of cleanly converting sensitive single compounds and complex mixtures in solution. They are recyclable and/or can be employed catalytically.

Oxidizing polymers and polymer-supported carbanion equivalents, in particular, have been employed successfully for preparation of protease inhibitor collections as a practically relevant example. With peptide aldehydes and differently substituted a-hydroxy-jS-amino carbonyl moieties two inhibitory motifs have been prepared with hitherto unprecedented ease and efficiency. Now it remains to be demonstrated that the synthetic methodology as introduced here is capable of assisting the identification of novel biologically active structures.

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