HHV6 infection can induce atypical lymphoproliferations

Atypical lymphoproliferations (APLs) constitute a heterogenous group of lesions that clinically mimic malignant lymphomas, but are lacking the criteria of mon-oclonality and malignant transformation. The incidence of APL seems to be increased in patients with immune disorders, and persistently active infection by lymphotropic viruses is frequently found in APLs. They can be defined as prema-lignant lymphoproliferations and may finally transform to malignant lymphomas. "Type B reticulum cell sarcoma'' or the Moloney and Gross virus-induced lymphoblastic lymphomas in mice represent similar polyclonal cell proliferations preceding virus-induced lymphomas. In humans, the majority of reported cases are associated with herpesvirus infections, namely EBV and/or HHV-6.

Table 1

HHV-6 prevalence in lymph nodes from HD patients

Table 1

HHV-6 prevalence in lymph nodes from HD patients

No. of

No. of

Subtype of

Assays

References

samples

positive (%)

positive HD

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