The data reviewed in this chapter describe various aspects of HHV-6 variants. Based on the findings, the following conclusions can be drawn:
1. The HHV-6A and B variants are two distinct viruses and should be reclassified according to the nomenclature of herpesviruses;
2. The existing epidemiology of HHV-6 is confusing because there are no sero-logical tests to assess the prevalence rates of variants A and B in various parts of the world.
3. More specific reagents and assays need to be developed to differentiate between active and latent infections, so that the infection can be controlled in the early stages.
4. Earlier reports and current studies have not been able to show clear-cut variant association with various diseases and disorders, or few attempts have been made to do so. More emphasis must be placed to type the variants in these diseases.
5. The consequences of HHV-6 infection and its concurrent complications are still being underestimated.
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