Only for a minority of genomic disorders have the breakpoints of the disease-causing rearrangements been mapped to specific intervals within duplicated sequences. However, for every case in which sufficient numbers of breakpoints have been precisely mapped, substantial NAHR rate heterogeneity within the duplicated sequence is observed. Table 1 documents the known NAHR hotspots. It can be seen that the list of rearrangements is only a small subset of the comprehensive list of genomic disorders given elsewhere in this book.
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