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background a The factor of enhancement (F) is calculated according to the equation below, which takes into account the size of the hotspot (H), the size of the contiguous duplicated block of appreciable homology (R), and the proportion of breakpoints found within the hotspot (q); F = Rq/H.

HERV, human endogenous retrovirus; NF1, neurofibromatosis 1; HNPP, hereditary neuropathy with liability to pressure palsies; CMT1A, Charcot-Marie-Tooth disease type 1A; SMS, Smith-Magenis syndrome; LCR, low-copy repeat; Chr., chromosome.

background a The factor of enhancement (F) is calculated according to the equation below, which takes into account the size of the hotspot (H), the size of the contiguous duplicated block of appreciable homology (R), and the proportion of breakpoints found within the hotspot (q); F = Rq/H.

HERV, human endogenous retrovirus; NF1, neurofibromatosis 1; HNPP, hereditary neuropathy with liability to pressure palsies; CMT1A, Charcot-Marie-Tooth disease type 1A; SMS, Smith-Magenis syndrome; LCR, low-copy repeat; Chr., chromosome.

autosomal region) or from patterns of LD (e.g., the MHC) and were subsequently fine-mapped in males using sperm typing methods. Other AHR hotspots were identified in sequences flanking minisatellites during studies of minisatellite mutation dynamics in sperm (reviewed by ref. 17).

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