Initial data on HDAC8 expression have been generated through the analysis of its transcript expression. The abundance and distribution of HDAC8 mRNA has indeed been examined by Northern blot, real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and serial analysis of gene expression (SAGE) in various human tissues and cells (1,2,4). It has been suggested that HDAC8 mRNA is ubiquitously expressed since this transcript could be detected in all normal human tissues examined (1-3). Intriguingly, different authors have observed HDAC8 transcript to be expressed at the highest levels in different organs, including normal human brain (1,3), pancreas (1,4), kidney (3,4), prostate (3), and liver (2). Nevertheless, the expression profile of HDAC8 mRNA has been found to be distinctly different from that of HDAC1 to 3 transcripts (3).
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