Ctip2

Endogenous SIRT1 and chicken ovalbumin upstream promotor transcription-factor-interacting protein 2 (CTIP2) copurify from human nuclear extracts, and both proteins interact directly in vivo and in vitro (93). CTIP2 represses transcription through its sequence-specific DNA binding activity. The transcriptional repression and deacetylation of promoter-bound histones H3 H4 observed upon CTIP2 transfection is reversed by nicotinamide treatment. Exogenous SIRT1 increases both transcriptional...

Ric Verdin md

Cancer Drug Discovery and Development Deoxynucleoside Analogs in Cancer Therapy, edited by Godefridus J. Peters, 2006 Cancer Drug Resistance, edited by Beverly A. Teicher, 2006 Histone Deacetylases Transcriptional Regulation and Other Cellular Functions, edited by Eric Verdin, 2006 Immunotherapy of Cancer, edited by Mary L. Disis, 2006 Biomarkers in Breast Cancer Molecular Diagnostics for Predicting and Monitoring Therapeutic Effect, edited by Giampietro Gasparini and Daniel F. Hayes, 2006...

References

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