Hdac3 Interacting Proteins

One of the biggest challenges in the study of HDAC3, as in the study of other HDACs, is to understand the exact mechanisms by which HDAC3 changes gene expression and how it affects the functions of the transcriptional machinery. Early in the studies of HDACs, the identification and characterization of HDAC1 2 binding proteins were tremendously useful in elucidating the mechanisms of action and functions of these two HDACs. Following similar strategies, Wen et al. isolated a large...

Inhibition Of Skeletal Muscle Differentiation By Class Ii Hdacmef2 Interactions

Investigators began focusing on potential roles for HDACs in the control of skeletal muscle differentiation following the discovery that MEF2 can physically associate with class II HDACs 4, 5, 7, and 9. MEF2-HDAC interactions were initially uncovered by yeast two-hybrid screens for MEF2 binding partners (6,7) and have now been confirmed employing a variety of independent biochemical techniques (8-12). Binding of class II HDACs to MEF2 is mediated by 18 conserved amino acids in the...

Other Biological Functions Of Hdac1

Transcriptional repression mediated by HDAC1 clearly plays a crucial role in regulation of cell cycle progression, proliferation, and differentiation. However, increasing evidence indicates that HDAC1 can also influence various other biological processes by mechanisms that do not necessarily involve transcriptional repression, as will be discussed in the following sections. PCNA is a crucial component of the DNA replication machinery (64). Physical interaction between HDAC1 and PCNA has been...

Ctip2

Endogenous SIRT1 and chicken ovalbumin upstream promotor transcription-factor-interacting protein 2 (CTIP2) copurify from human nuclear extracts, and both proteins interact directly in vivo and in vitro (93). CTIP2 represses transcription through its sequence-specific DNA binding activity. The transcriptional repression and deacetylation of promoter-bound histones H3 H4 observed upon CTIP2 transfection is reversed by nicotinamide treatment. Exogenous SIRT1 increases both transcriptional...

Ric Verdin md

Cancer Drug Discovery and Development Deoxynucleoside Analogs in Cancer Therapy, edited by Godefridus J. Peters, 2006 Cancer Drug Resistance, edited by Beverly A. Teicher, 2006 Histone Deacetylases Transcriptional Regulation and Other Cellular Functions, edited by Eric Verdin, 2006 Immunotherapy of Cancer, edited by Mary L. Disis, 2006 Biomarkers in Breast Cancer Molecular Diagnostics for Predicting and Monitoring Therapeutic Effect, edited by Giampietro Gasparini and Daniel F. Hayes, 2006...

References

Taunton J, Hassig CA, Schreiber SL. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 1996 272 408-411. 2. Vidal M, Gaber RF. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol Cell Biol 1991 11 6317-6327. 3. Yang WM, Inouye C, Zeng Y, Bearss D, Seto E. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global...