Possible Consequences for Bacterial Ecology due to Antibiotic Treatment in HS

Acne No More Ebook

Natural Acne Cure and Treatment

Get Instant Access

The drawback to the usefulness of long-term antibiotic treatments is concern about the effect on microbial ecology (Table 11.5). The normal microflora act as a barrier against colonization by potentially pathogenic bacteria and the control of growth of opportunistic bacteria is called colonization resistance. The normal equilibrium between host and microorganisms may be disturbed by a number of factors, but commonly and essentially by antibiotic therapy. To what extent disturbances occur depends of numerous factors: the spectrum of the antibiotic, the dose, the route of administration, pharmacokinetic and pharmacodynamic properties and in vivo inactivation of the drug [53].

Clindamycin administration results in major ecological disturbances in intestinal and oro-pharyngeal microflora: the numbers of entero-coccal species increase and those of all anaerobes decrease [39, 51]. A possible complication of clindamycin treatment is pseudomembra-nous colitis, which occurs when antibiotics such as clindamycin, ampicillin and third-generation cephalosporins suppress the normal flora, allowing Clostridium difficile to grow and produce toxins [40]. Rifampicin treatment was shown to lead to a decrease in total aerobic and anaerobic oral bacteria in healthy volunteers [1].

The emergence of antimicrobial resistance is strongly associated with the clinical use of the antibiotics and a balanced microflora prevents establishment of resistant strains of bacteria [53]. It is well known that oral antibiotics select for resistant bacteria at all body sites where there is a normal flora: skin, conjunctivae, oral cavity, nasopharynx, upper respiratory tract, intestinal tract, and vagina [16]. A therapy administered for a long period, as was recommended in HS treatment [25], will exert a high pressure for the development of the resistant strains of Propionibacterium acnes, coagulase-negative staphylo-

Table 11.5. Effects of antibiotic administration on the ecological balance of human microflora

- Disturbances in the balance between host and normal flora from the intestinal tract, skin, oropharyngeal tract, and vagina

- Altered colonization resistance (growth control of opportunistic bacteria)

- Overgrowth of pathogenic bacteria or yeasts

- The emergence of antimicrobial resistance in the normal flora

- Possible transfer of resistance to pathogenic bacteria cocci on the skin, Staphylococcus aureus in the nares, streptococci in the oral cavity, and en-terobacteria in the gut [16].

Topical clindamycin will increase carriage of Propionibacterium acnes and Staphylococcus epidermidis resistant strains on skin and there is a risk of transfer of resistance to other pathogenic bacteria, Staphylococcus aureus and Streptococcus species [15]. The skin and conjunctivae flora from untreated sites will also be affected by transfer of antibiotic [16].

In conclusion, antibacterial drugs represent an adjuvant treatment in HS. They are not curative but they reduce odor and discharge, and diminish pain. Antibiotics represent a palliative therapy that may control the disease in early stages and can reduce the inflammation before and after surgery [28] but clinicians should be aware about the downside of taking them.

Was this article helpful?

0 0
Solve Your Acne Problems

Solve Your Acne Problems

Solve Your Acne Problems With These Simple Home Remedies.

Get My Free Ebook

Post a comment