HS is a relatively common skin disease affecting about 1% of the general population. Both genetic and environmental factors have been identified as potential causative factors but assessment of their importance is hampered by the lack of systematic analyses considering potential confounding effects and interactions. For the future a larger collaborative research network promoting more systematic research activity would be desirable. Relatively simple measures, such as prevalence rates, are of great interest if obtained according to uniform methods in different countries, e.g., several European countries, allowing international comparison and ecological correlations. The development of HS is likely due to the effect of concurrent etiologic factors, which should be better assessed in a simultaneous way. Family history and smoking habits are well established causes. They should be considered in any future etiologic study including genetic studies where a genetics-environmental interaction may play a role. An area in urgent need of attention is clinical epidemiology. Perhaps the best way to analyze outcomes and associated factors (i.e., etiologic and predicting factors) is through long-term cohort studies of representative samples of newly diagnosed HS patients. In the context of a cohort, risk factors for disease relapse or other "sentinel" events, e.g., cancer development, could be efficiently evaluated by nested case-control studies or case-cohort analyses. Finally, large-scale pragmatic randomized trials would be the best way to evaluate the impact of complex or non-pharmacological interventions (e.g., lifestyle changes) on disease progression.

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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