Non Skin Cancers

Growth of sinus tracts is a histological hallmark of HS. Histologically the sinus tracts often appear as pseudo-neoplastic changes, and the co-occurrence of actual cancer is therefore not only of clinical interest, but of potentially pathogenic relevance as well, and may reflect an overall trend for HS patients. To our knowledge, there is only one epidemiological study, from Sweden, addressing this matter [68]. This registry-based study concerned the relative incidence of cancer in patients treated for HS in the period from 1965 until 1997. In total 2119 patients were included. The overall risk of any cancer was increased by 50% (standardized incidence rate 95%, confidence interval 1.1-1.8) among this cohort of patients hospitalized for HS, based on the finding of 73 cases of cancer in HS patients and comparing the figure to the expected incidence in the general Swedish population. The average age at diagnosis of cancer was 51.2 years for women and 55 years for men. There was a

significantly increased relative risk not only for non-melanoma skin cancer but also for buccal cancer and primary liver cancer. Whether this increased relative risk was correlated with alcoholism and/or smoking could not be ascertained in this study. The data suggest a co-occurrence of HS and cancer but these observations await confirmation in other HS populations. If confirmed it may give direction to further aetio-logical and pathogenic research in HS.

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