Mechanism of Action

There is a broad base of clinical experience with etretinate and acitretin in the treatment of chronic keratinizing disorders [33]. If ductal hy-perkeratinization is crucial in the pathogenesis of HS, etretinate and acitretin could be good alternatives to isotretinoin, because these drugs have a clearly greater effect on hyperkeratiniza-tion [3]. In addition, etretinate and acitretin show considerable immunomodulatory and anti-inflammatory effects [33]. Acitretin, the active retinoid metabolite, has generally replaced etretinate in retinoid therapy, certainly in psoriasis because of its more favorable phar-macokinetic profile, including a significantly shorter half-life.

Cure Tennis Elbow Without Surgery

Cure Tennis Elbow Without Surgery

Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.

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