Key points

■ An association between hidradenitis suppurativa (HS) and Crohn's disease (CD) appears to be well established

■ Recognizing HS in a patient with CD, or vice versa, has no immediate major therapeutic implications but may lead to the choice of a more aggressive medical strategy

■ One can expect that a genetic link between the two diseases will be demonstrated and may lead to the development of specific targeted therapies

Contents

Genetic Factors

Enteric Microflora

Immune-Mediated Tissue Injury

Pathology

Clinical Aspects

Disease Location

Clinical Presentation

Therapeutic Aspects and Prognosis

Cutaneous Crohn's Disease

Clinical Presentation of Cutaneous Lesions

Therapeutic Aspects and Prognosis

7.6

Crohn's Disease

and Hidradenitis Suppurativa

53

7.6.1

Differential Diagnosis

53

7.7

Co-Existence of HS and CD

55

7.8

Treatment of Perianal Co-existent CD

and HS

55

References

55

Definition and Course of Crohn's Disease 50

Pathophysiology 50

Crohn's disease (CD) is a chronic granuloma-tous inflammatory bowel disease that may involve the anus and the perianal region. About 50% of patients with CD develop perianal lesions during the course of their disease. In some of these patients, perianal cutaneous lesions may mimic those of HS. Moreover, the occurrence of both HS and CD in the same individual has been reported in quite a large number of cases. This paper reviews the main pathophysi-ological and clinical aspects of CD, describes the perianal lesions of CD, comparing them to those of HS, and discusses the links between the two diseases.

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