Key points

■ Hidradenitis suppurativa (HS) is resistant to current medical management options

■ The association with Crohn's disease (CD) suggests an inflammatory etiology

■ Infliximab has been shown to induce durable remissions in patients with HS and HS/CD

■ The efficacy of infliximab suggests a role for tumor necrosis factor alpha (TNFa) in the etiology and pathogen-esis of HS

■ The efficacy of infliximab in HS suggests a role for broadening the therapeutic applications of TNFa inhibitors

Contents

20.1 Introduction 145

20.2 Background 145

20.2.1 Crohn'sDisease and Hidradenitis

Suppurativa Co-Occurrence: A Rationale for Anti-TNF Therapy 147

20.3 Anti-TNF Drugs in HS 147

20.4 Future Prospects 148

References 149

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