Key points

■ HS is a follicular disease

■ Apocrine gland involvement appears to be secondary to follicular events

■ A lymphocytic infiltrate predominates in early lesions

■ Keratin expression suggests that sinus tracts are fragile

■ Keratin expression suggests that the outer root sheet may be involved in HS lesions

Contents

4.1 Introduction 25

4.2 Glandular Elements of the Skin 26

4.2.1 Sebaceous Glands and the Pilosebaceous Unit 26

4.2.2 Apocrine Glands 27

4.2.3 Eccrine Glands 27

4.2.4 Apoeccrine Glands 27

4.3 Histological Appearance of HS 27

4.3.1 Early Lesions 27

4.3.2 Established Hidradenitis Suppurativa . . 28

4.4 Immunohistochemistry of Hidradenitis Suppurativa 30

4.5 Cytokeratin Expression in HS 30

4.6 Comparison with Other Disorders 31

4.6.1 Fox-Fordyce Disease 31

4.6.3 Follicular Occlusion Triad 31

4.6.4 Pilonidal Sinus 31

4.6.5 Crohn's Disease 32

4.7 Conclusions 32

Acknowledgements 33

References 33

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