HS and Biological Hyperandrogenism

Furthermore, as far as serum levels of andro-gens and SHBG are concerned, there is no clear evidence for biochemical hyperandrogenism. On average, androgen levels (total plasma testosterone and free testosterone index due to a low SHBG) were increased, but were normal in many individual patients, and no significant decrease of SHBG could be detected [13]. In fact, SHBG is known to be regulated by factors that influence body weight and this study was not controlled for body weight, and neither was a second one which found hyperandrogenism in a subgroup of women who did not experience a premenstrual flare in their disease [9]. In a further group of 66 women with HS, among which 23 had acne, 23 were significantly obese and 19

were hirsute; testosterone and DHEAS were normal in all subjects [3]. In obese subjects, SHBG was reduced, consistent with body-mass-index-matched controls. No evidence for biochemical hyperandrogenism could be found in women with HS when compared with controls matched for age, weight, and hirsuteness [3].

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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