Zinc's efficacy in Verneuil's disease is probably due to its anti-inflammatory activity. It has activity against various targets implicated in the cutaneous inflammatory reaction and the mechanism of action is still only partially understood.

As for non-specific immunity, 30 mg zinc metal [3] inhibits the chemotactic migration of granulocytes, both in vitro and in vivo. It activates natural killer cells and the phagocytic function of granulocytes [4].

Zinc also inhibits the expression of integrins by keratinocytes in inflammatory lesions, i.e. ICAM 1 and LFA 3, which play an important role in the interactions between keratinocytes and lymphocytes [5].

The production of two main inflammatory cytokines produced by keratinocytes in inflammatory lesions, namely tumour necrosis factor alpha (TNFa) and interleukin-6 (IL-6), is inhibited by zinc salts [6]. In addition, zinc has an anti-oxidant activity, by inducing the expression of the enzyme Zn- Cu superoxide dismutase, which is present in keratinocytes and fibroblasts; thus, it increases the elimination of free radicals. As for T-cell-mediated immunity, zinc is a cofactor of thymulin, which is a thymic cyto-kine implicated in the maturation of T lymphocytes.

Zinc stimulates the migration of keratinocytes, which play an important role in the healing of cutaneous wounds, by stimulating a3, a5 and pi integrin functions [8, 9].

Cure Tennis Elbow Without Surgery

Cure Tennis Elbow Without Surgery

Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.

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