Discussion

Two regions have been identified that are possible loci for HS. One of these loci, on chromosome 6, yielded a statistically significant 2-point LOD score when the linkage data from two families were combined. This locus should therefore be treated with caution since it would be preferable to obtain a significant LOD score of >3.0 using data from one family only, so that there is less likelihood of any spurious linkage effects. Nevertheless, the known genes within the chromosome 6 locus have been fully sequenced without the identification of any potentially pathogenic mutations. Other genes in this region may yet be discovered as there are human mRNA sequences aligned to 6q25.2 that do not correspond to any of the known genes and may turn out to be expressed genes that are as yet unknown.

The region of chromosome 19 spanning the centromere constitutes the second candidate region. This locus gave a statistically significant LOD score with data from one family and therefore represents a more robust linkage result than the 6q locus. This linked interval contains at least 21 genes, some of which have an unknown function and some that are predicted proteins. Only seven genes were chosen whose function or homology to other proteins made them good potential candidate HS genes. No mutations were found in any of these genes but there are still a number of other genes to screen that may carry a mutation. In addition, the causative mutation may have been missed, as discussed below.

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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