Cytokeratin Expression in HS

Cytokeratin (CK) is an important marker for evaluating the origin and state of differentiation of epithelial cells. CK17 (found in normal in-fundibulum, Fig. 4.6) has been shown to be absent from infundibular-like keratinized epithelium from HS lesions. This suggests fragility of the draining sinus epithelial, which may allow rupture to occur more easily, thus resulting in a subcutaneous abscess. Keratin expression in non-infundibular keratinized and non-keratin-ized epithelium of HS lesions has been shown to be similar to that observed in the outer root sheath in normal hair follicles [18]. Hence draining sinus epithelium in HS may possess characteristics of undifferentiation and hyperprolifer-ation.

Fig. 4.6. Normal pilosebaceous unit, CK17 was present in suprabasal layers of the infundibulum (original magnification x100)

Fig. 4.5. CD4 cells around the follicular duct

Fig. 4.6. Normal pilosebaceous unit, CK17 was present in suprabasal layers of the infundibulum (original magnification x100)

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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