One of the less sex-specific effects of androgens is that on the skin and its appendages, and in particular their action on the pilosebaceous unit. Hirsutism is the major symptom of hyper-androgenism in women. Other dermatological conditions include acne and the chronic hair loss usually termed androgenic alopecia (AGA). Whereas acne, hirsutism and chronic hair loss may coexist in the same patient, it is not unusual to find only one of these androgenic manifestations [16].

Depending on the presence of ovarian dysfunction, extracutaneous manifestations may include abnormalities of menstruation with anovulatory patterns, oligomenorrhoea, fertility problems, android obesity and risks for metabolic complications, such as hyperinsulin-ism, insulin resistance, diabetes mellitus, and dyslipidaemia, and for cardiovascular diseases [6, 16].

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