Postherpetic Neuralgia and Other Neurologic Complications

Postherpetic Neuralgia

Neurological Clinic, Pain Research and Therapy, University Kiel, Kiel, Germany The acute herpes zoster radiculoneuritis affects mainly elderly patients with an incidence of 125 100,000 per year. The clinical onset of acute herpes zoster infection is heralded by pain in the affected segment (preherpetic neuralgia). The characteristic vesicopapular rash usually appears a few days after the onset of pain and takes 3-4 weeks to heal. In most patients, the rash and pain disappear completely within a...

Antiviral Therapy of Shingles in Dermatology

Dermatology Department, Klinikum Krefeld, Krefeld, Germany The major goals of therapy in patients with herpes zoster are (1) shortening of virus replication, (2) prevention of dissemination of skin lesions, (3) reduction of acute zoster-associated pain (ZAP), (4) prevention of chronic ZAP and postherpetic neuralgia (PHN), (5) prevention of other complications, e.g. ophthalmic involvement. Recent research has shown that antiviral therapy with acyclovir, valacy- clovir, famciclovir, and brivudin,...

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At present, molecular biological methods should be regularly included in the diagnosis of CVS. In particular, cases presented with rare malformations or after subclinical maternal VZV infection need confirmation by virological methods, otherwise the causal relationship between maternal infection and congenital abnormalities remains doubtful 26 . Suspected prenatal infection with VZV is usually confirmed by detection of VZV-specific antibodies. Serologic diagnosis is mostly based...

Varicella Zoster Virus Infections during Pregnancy

Institute of Virology and Antiviral Therapy, Friedrich-Schiller University, Jena, Germany Frequency and Consequences ofVaricella-Zoster In most industrial countries, chickenpox is a rare disease during pregnancy as more than 90 of women of child-bearing age possess virus-specific IgG class antibodies. Only 3-4 of women in Germany were found to be susceptible to primary varicella-zoster virus (VZV) infection 1 . In early reports, the average incidence of varicella in pregnant women was...

Epidemiology of Herpes Zoster What has Changed

Segmente Zoster

Regina Allwinn, Sigune Buxbaum, Hans Wilhelm Doerr Institute for Medical Virology, University Hospital of Frankfurt, Frankfurt am Main, Germany Herpes zoster (shingles) is an inflammatory neurodermatologic disease, usually localized on a skin segment of the body which is innervated by a sensory nerve. More than 100 years ago, an association between Varicella and herpes zoster has been suggested (see preface of the book). Shingles is a secondary disease to passed Varicella virus (VZV) infection,...

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Herpes zoster in 2,149 HIV-infected patients. Blue HIV with herpes zoster. Green HIV without herpes zoster. herpes zoster suffered from Kaposi's sarcoma with or after herpes zoster , whereas Kaposi's sarcoma occurred in 21.5 of all 2,149 HIV-infected patients at our clinic. A possible explanation for this comorbidity could be the fact, that both diseases are due to viruses from the herpes virus family VZV and HHV-8 . Within this family of eight pathogen viruses, co-infections with two...