Resistance to Interferons

Interferonsare oftenusedaspartoftreatment therapiesfor HDV(as discussed in chapters by J.S. Glenn and J.L. Casey and J.L. Gerin, this volume). However, when applied to HDV replication as it occurs in cultured cells in the absence of HBV, no such inhibition has been detected with interferons a or y (Chang et al. 2006; Ilan et al. 1992; McNair et al. 1993). In apparent contrast, a fraction of patient therapies are successful with high dose interferon treatments (Kleiner et al. 1993; Lau et al. 1999). However, it might be that these treatments are interfering with HDV indirectly, by inhibiting the helper virus HBV.

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