Control of Hdv Rna Editing

Control of HDV RNA editing occurs on several levels. First, the HDV antigenome contains about 337 adenosines, but editing is highly specific for the amber/W site. Second, both the rate and extent of editing appear to be carefully controlled. Some host substrates for editing exhibit modification rates approaching 100%, and this editing likely occurs rapidly; most known host substrates are pre-mRNAs that are edited prior to splicing. In contrast, for HDV, edited viral RNAs accumulate slowly and levels typically plateau at less than 30% edited after 12 days in transfected cells in culture.

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