Regulation of Myocardial Blood Flow

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Myocardial Substrate Selection

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Drake-Holland, A.J., Van der Vusse, G.J., Roemen, T.H., et al. (2001) Chronic catecholamine depletion switches myocardium from carbohydrate to lipid utilisation. Cardiovasc Drugs Ther. 15, 111-117.

Lehman, J.J. and Kelly, D.P. (2002) Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol. 29, 339-345.

Glucose and Fatty Acid Metabolism, Tricarboxylic Acid Cycle Function, and Electron Transport Chain Function

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Intermediary Metabolism and Oxidative Phosphorylation

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Cortassa, S., Aon, M.A., Marban, E., Winslow, R.L., and O'Rourke, B. (2003) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J. 84, 2734-2755.

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Hochachka, P.W. (2003) Intracellular convection, homeostasis and metabolic regulation. J Exp Biol. 206, 2001-2009.

Korzeniewski, B. (2001) Theoretical studies on the regulation of oxidative phosphorylation in intact tissues. Biochem Biophys Acta. 1504, 31-45.

Korzeniewski, B. (2002) Parallel activation in the ATP supply-demand system lessens the impact of inborn enzyme deficiencies, inhibitors, poisons or substrate shortage on oxidative phosphorylation in vivo. Biophys Chem. 96, 21-31.

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Territo, P.R., Mootha, V.K., French, S.A., and Balaban, R.S. (2000) Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase. Am J Physiol Cell Physiol. 278, C423-C435.

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High-Energy Phosphate Shuttles

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Metabolism During Ischemia

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Metabolism in Hypertrophied and Failing Myocardium

Lehman, J.J. and Kelly, D.P. (2002) Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol. 29, 339-345.

Liao, R., Jain, M., Cui, L., et al. (2002) Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation. 106, 2125-2131.

Ning, X.H., Zhang, J., Liu, J., et al. (2000) Signaling and expression for mitochondrial membrane proteins during left ventricular remodeling and contractile failure after myocardial infarction. J Am Coll Cardiol. 36, 282-287.

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Inherited Defects in Myocardial Metabolism

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Roe, C.R., Sweetman, L., Roe, D.S., David, F., and Brunengraber, H. (2002) Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest. 110, 259-269.

Your Heart and Nutrition

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