Treatment

Admission to a burn or intensive care unit can result in significant reduction in morbidity and mortality. Treatment is supportive and includes fluid and electrolyte imbalance corrections, strict monitoring of urinary output, caloric replacement, prevention of secondary infections, good skin and ophthalmologic care, and physical therapy. If there are large areas of denudation, the use of biological dressings or skin equivalents is recommended. Corticosteroids have been used to treat SJS in the past, but there are no clinical trials demonstrating efficacy, and recent retrospective studies suggest corticoster-oids may adversely affect morbidity and mortality. Intravenous immunoglobulin (IVIG) has shown some promise when recently studied in nonblinded, nonplacebo-controlled clinical trials. Days with fever were reduced by 50%, but the general course of the disease was not influenced compared to historical controls.

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