Manifestations of SLE occur through a variety of pathogenetic mechanisms. Lesional skin biopsies can demonstrate inflammation and degeneration of the dermo-epidermal junction. Granular deposits of immunoglobulins and complement components can be seen, often in a band-like pattern, under immunofluorescent microscopy. Frank vasculitis can affect small blood vessels as well. Whether otorhinolaryngeal manifestations such as autoimmune hearing loss seen in association with SLE result primarily from autoantibody-mediated events, or vasculitis, or a combination of inflammatory and immune events, is largely unknown. Some neurologic manifestations of SLE have been associated with antiphospholipid antibodies, giving rise to the possibility that pathogenesis could be linked to thrombosis.
Was this article helpful?
Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.