SJS is a severe illness with significant morbidity and mortality. It is characterized by an abrupt onset of mucocutaneous necrosis of at least two mucosal sites with variable skin involvement, following a characteristic prodrome of a respiratory illness. Most commonly, SJS is drug-induced, but many causative factors have been implicated. Treatment consists of supportive care and discontinuation of the offending agent; administration of corticosteroids or IVIG is controversial and not evidence-based. Please see Chapter 22 for further discussion of SJS.

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