Prognosis

After an episode of CSD, healthy individuals usually develop lifelong immunity, preventing reinfection. In children with normal immune systems, spontaneous healing with full recovery is the norm, usually with complete resolution of lymphadenopathy after two to six months. In immunocompromised people, treatment with antibiotics generally leads to recovery, with the order of preferred antibiotic agent as follows: rifampin, ciprofloxacin, gentamicin, and trimethoprim-sulfamethoxazole (9). Azithromycin may shorten the duration of lymphadenopathy, as was demonstrated in a small, prospective, comparative study. Complications of CSD include Parinaud's syndrome, encephalopathy, neuroretinitis, and osteomyelitis.

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