Mucormycosis in Children

In addition to cases involving immunosuppressed children, mucormycosis also has been observed in neonates (especially very-low-birth-weight premature infants weighing less than 1000 g), burn patients, and children with a history of incidental trauma. As with adult patients, the occurrence of mucormycosis depends on host immunity, but the mechanisms of increased susceptibility in certain hosts remain perplexing. In a pooled review by Kline of 41 cases of RCM in children aged 2 months to 18 years, 49% of cases were found in children with diabetes mellitus and 15% of cases were found in children with leukemia (10). In 10% of cases in these children, no predisposing conditions were present. In neonates, these invasive fungal infections have been observed to be rapidly fatal; the time from clinical symptoms to death ranges from 6 to 42 days.

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