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Systemic Allergic Disorders: IgE-Mediated Disorders, Angioedema, Nonsteroidal Anti-Inflammatory Drug Sensitivity, and Stevens-Johnson Syndrome

Michelle Hernandez and Stephen I. Wasserman

Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, California, U.S.A.

■ Introduction 317

■ IgE-Mediated Disorders 317

■ Allergic Rhinosinusitis 317

■ Definition 317

■ Epidemiology 317

■ Pathogenesis 318

■ Clinical Manifestations 318

■ Diagnosis 319

■ Treatment 319

■ Complications 321

■ Prognosis 321

■ Angioedema 322

■ Introduction 322

■ Definition 322

■ Epidemiology 322

■ Pathogenesis 323

■ Clinical Manifestations 324

■ Diagnosis and Differential Diagnosis 324

■ Treatment 324

■ Complications and Prognosis 325

■ Aspirin (NSAID) Hypersensitivity 325

■ Introduction 325

■ Definition 326

■ Epidemiology 326

■ Pathogenesis 326

■ Clinical Manifestations 326

■ Diagnosis 327

■ Treatment 327

■ Complications and Prognosis 328

■ Stevens-Johnson Syndrome 328

■ Introduction 328

■ Definition 329

■ Epidemiology 329

■ Pathogenesis 329

■ Clinical Manifestations 330

■ Diagnosis and Differential Diagnosis 330

■ Treatment 330

■ Complications and Prognosis 331

■ References 331

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