Definition

Glucagon-secreting tumors of the pancreatic islets (glucagonomas) produce a distinctive syndrome characterized by the development of prominent mucocutaneous findings, adult-onset diabetes mellitus, weight loss, and anemia (18). Becker initially described the constellation of symptoms associated with an islet tumor of the pancreas in 1942.

The cutaneous component of this syndrome, termed necrolytic migratory erythema (NME), was first described by Wilkinson in his report of a patient with pancreatic carcinoma in 1973. The full syndrome was finally described by Mallison in 1974 in his review of nine patients with glucagon-secreting tumors.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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