Definition

HIV infection is prevalent worldwide and is universally fatal if left untreated, leading to and being the etiologic agent of AIDS. Initial reports in 1981 of cases of men who have sex with men in major U.S. cities, presenting with a combination of malignancies and infections usually encountered in severe immunosuppression, were quickly followed by the definition of what we know today as AIDS. The Centers for Disease Control (CDC) published the current case definition criteria in 1993 (7), which include a set of clinical parameters in three different categories and also three categories of quantification of the primary cellular immunologic marker of the infection, the CD4+ T-lymphocyte count (CD4 cell) (Table 1).

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