Clinical Manifestations

Classic symptoms of infectious mononucleosis are the triad of fever, pharyngitis, and cervical lymphadenopathy. In addition to fever, systemic symptoms include fatigue and generalized lymphadenopathy. Oral hairy leukoplakia, a collection of hairy or corrugated white lesions located on the lateral surface of the tongue, is common. Sometimes splenomegaly or mild hepatitis may develop. Uncommon manifestations include heart problems, jaundice, pneumonitis, blood dyscrasia, and cerebritis (2). In patients with HIV infection, infection of epithelial cells by EBV is often represented by oral hairy leukoplakia.

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