Hay Fever Home Remedies
Polysaccharides from soy sauce have been shown to have anti-allergic activities in vitro and in vivo and an 8-week double blind study involving 51 subjects with seasonal allergic rhinitis found that oral supplementation with 600 mg of soy polysaccharides was effective in significantly improving symptom scores such as sneezing, nasal stuffiness, and hindrance of daily life, as well as significantly improving the appearance and state of the nasal mucosa (Kobayashi 2005, Kobayashi et al 2005).
Mast cells participate both in acquired (e.g., IgE-dependent) and innate immune responses and tend to be present in tissues that interface between the organism and its environment (e.g., skin, respiratory tract, gastrointestinal tract) (121,122). The IgE-dependent roles of mast cells in allergic reactions, hay fever, and asthma are well established (121-123). Allergens and Ags recognize and crosslink specific IgE bound to the cell surface high-affinity IgE receptor, FceRI, to trigger acute hypersensitivity reactions, late-phase reactions, and chronic inflammatory reactions by release of preformed mediators present in the cytoplasmic granules (biogenic amines, proteoglycans, neutral proteases, TNF-a) and de novo synthesized mediators (leukotrienes, prostaglandins, cytokines).
There is clear evidence that otitis media with effusion is highly related to an allergic diathesis. When this converts to chronic draining otitis media, the allergic component would seem to still be relevant, although direct evidence is scant (17-19). Therefore, the surgeon must consider allergy evaluation, based on a patient history of other allergic diatheses, especially of the unified respiratory epithelium. Patients with chronic draining ear and allergic rhinitis, chronic rhinosinusitis, and asthma are strong candidates for allergy workup before contemplating surgical treatment.
Seed extract Perilla seed extract, as well as its constituents luteolin, rosmarinic acid and chrysoeriol, have been shown to inhibit 5-lipoxygenase in vitro, and therefore leukotriene synthesis. Leukotrienes are associated with both allergic and inflammatory disorders, including hay fever, asthma and inflammatory bowel disorders.
A more effective approach to nasal congestion and inflammation is the use of a topical nasal corticosteroid spray. This class of agent is the most potent and effective modality for the treatment of allergic rhinitis and is effective against all of the manifestations of this disorder (8). Common side effects include local nasal irritation and occasional thrush. Less common, but possibly important in the case of long-term use, are an increase in incidence of glaucoma, cataracts, and osteoporosis. These drugs diminish the inflammatory influx of cells into the nasal mucosa and diminish the strength of the local allergic response.
Albizia is a traditional Ayurvedic medicine used to reduce allergic conditions, such as allergic rhinitis and urticaria. It is also used for atopic conditions, such as eczema and asthma, when indicated. Controlled trials have not been conducted, so it is uncertain whether it is effective. When will it start to work
Atopic dermatitis (AD) is a clinical syndrome characterized by an itchy rash with a variety of morphological cutaneous features that change with age, in association with a positive family history and concomitant presence of other atopic diseases (atopic asthma, hay fever, and occasionally urticaria) (Williams, 1997). The atopic immunological state is characterized by a propensity to develop type 1 IgE mediated responses in response to certain antigens, but the cutaneous immuno-pathology of atopic dermatitis is characterized by the presence of a T cell and inflammatory cell infiltrate resembling the pattern seen in type IV hypersensitivity reactions (rather than the type 1-like response seen in urticaria). The onset of the rash is typically in early life, peaking at age four years and tending to improve with age, although a large proportion of subjects may develop other forms of eczema later in life (Williams, 1997). Drawing the boundary between mild atopic dermatitis and normality is...
Allergic fungal rhinosinusitis (AFRS or AFS in the literature) is a hypersensitivity disease of the paranasal sinuses afflicting patients who are immunocompetent albeit with a history of atopy and allergic rhinitis to fungi. The disease process begins as the fungi become entrapped within the nasal cavity, presumably because of ostium obstruction or mucociliary disorder, and initiate a hypersensitive immune response. Just as with the other forms of fungal sinusitis, A. fumigatus is the most common etiological agent associated with AFRS (Table 1.1).
Also Lactobacillus strains have been shown to confer differential effects on cytokine production and expression of surface markers on murine dendritic cells (85). Furthermore, lactobacilli induced in vitro, in a strain dependent manner, Treg-like low proliferating Th population producing TGF-b and IL-10 (86). TGF-b is the key cytokine in induction of T-cell differentiation towards Tregs (Fig. 2) (87). In a clinical study, improvement in atopic eczema symptoms following oral administration of lactobacilli was accompanied by increased serum concentrations of TGF-b (17). Interestingly, oral supplementation of lactobacilli in breast-feeding mothers was followed by increased TGF-b concentrations in breast-milk (88). This increase may have contributed to subsequently lower prevalence of atopic eczema in children. It should be noted, however, that allergic sensitization was not affected and allergic rhinitis and asthma may have increased in frequency (89). Nevertheless, these studies are not...
Patients with this syndrome, pansinusitis is common. Although nasal polyps may complicate ordinary allergic rhinitis (approximately 1-2 in some studies) and are a common manifestation of cystic fibrosis (up to 50 of such patients), the highest incidence of nasal polyps occurs in the patients with NSAID hypersensitivity (up to 90 ). Such polyps often respond to systemic steroid treatment but may recur within days of its cessation.
Mast cells are large and are widely distributed in connective tissues, where they are usually located near blood vessels (fig. 5.15). They release heparin, a compound that prevents blood clotting. Mast cells also release histamine, a substance that promotes some of the reactions associated with inflammation and allergies, such as asthma and hay fever (see chapter 16, page 672).
Membranes of widely distributed mast cells and basophils. When a subsequent allergen-antibody reaction occurs, these cells release allergy mediators such as histamine, prostaglandin D2, and leukotrienes (fig. 16.24). These substances cause a variety of physiological effects, including dilation of blood vessels, increased vascular permeability that swells tissues, contraction of bronchial and intestinal smooth muscles, and increased mucus production. The result is a severe inflammation reaction that is responsible for the symptoms of the allergy, such as hives, hay fever, asthma, eczema, or gastric disturbances.
(British Thoracic Society Scottish Intercollegiate Guidelines Network, 2003). Asthma is strongly associated with atopy as demonstrated by the link with eczema and hay fever and the detection of IgE, or a positive skin prick test, to a specific allergen (Witt et al., 1986 Woolcock et al., 1987). Asthma is termed extrinsic if it is associated with atopy and intrinsic if it occurs in the absence of atopy.
Quercetin is used in the treatment of acute and chronic allergic symptoms, such as hayfever and chronic rhinitis. The anti-inflammatory activity of quercetin and its ability to stabilise mast cells, neutrophils and basophils and inhibit histamine release (Blackburn et al 1987, Busse et al 1984, Middleton & Drzewiecki 1982, Middleton et al 1981, Ogasawara et al 1996, Pearce et al 1984) provides a rationale for its use in these indications. In a study of 123 patients sensitised to house dust mite and displaying nasal symptoms of mild to severe perennial allergic rhinitis (Otsuka et al 1995), nasal scrapings were taken and histamine release measured as a percentage of the total content in the specimen. Antigen exposure resulted in an increase in mast cells of the epithelial layer of the nasal mucosa resulting in nasal hypersensitivity. Quercetin inhibited histamine release by 46-96 in a dose-dependent manner.