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FIGURE 13-19 Examples of antiestrogenic and antiprogestinal compounds. Each category of antagonist can be divided into class I (partial antagonist) or class II (pure antagonist).

TABLE 13-7 Proposed Steps in Steroid Hormone Action for Site of Action of Steroid Antagonists (Antihormones)

Transport through blood on serum protein Entry into target cell Receptor binding by Iigand

Competition with natural hormone Allosteric modification of natural hormone binding Generation of a new conformational form of the receptor Receptor-ligand actions

Interference with receptor dimer formation (either homo- or heterodimers)

Reduction or inhibition of transcription-activating function(s)

TABLE 13-8 Examples of Steroid Antagonists
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