Conclusion

In this brief chapter, we have discussed the relationship of hormones to cancer. Because cancer represents an escape from normal cellular regulation in terms of signal transduction, it is not surprising that hormones and their receptors are intimately related to carcinogenesis. In fact, carcinogens might be considered as external or xenobiotic hormones. There is great resemblance between the structures of some carcinogens and normal hormones. One of the chief mechanisms for escape of the normal signal transduction controls is the overexpression of oncogenes that are functional parts of receptors without the ligand-binding domain, a perfect solution by the aberrant cell to shortcutting the external signal. No doubt, new oncogenes will be-discovered that affect all levels of the signal transduction pathway, involving receptor processing and transcriptional controls.

10 Ways To Fight Off Cancer

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