Clinical Aspects

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A. Abortion

There is good evidence that PGs participate in various aspects of the ovarian cycle. In particular, PGF2a has been implicated as one of the factors effective in causing terminal contractions on the uterine myometrium. The levels of PGF2a in amniotic fluid align with the progress of labor during the birth process. Administered PG in

FIGURE 16-25 Outline of the reactions thought to occur in asthma. Abbreviations: H, histamine; PAF, platelet-activating factor; LTB4, LTC4, and LTD4, leukotrienes B4, C4, and D4; EMBP, eosinophil major basic protein; ECP, eosinophil cationic protein. Note that not all asthmatic subjects respond to cromolyn sodium or nedocromil sodium and that theophylline is only a second-line drug. Reproduced with permission from Rang, H. P., Dale, M. M., Ritter, J. M., and Gardner, P. (1995). "Pharmacology." Churchill-Livingstone, New York.

FIGURE 16-25 Outline of the reactions thought to occur in asthma. Abbreviations: H, histamine; PAF, platelet-activating factor; LTB4, LTC4, and LTD4, leukotrienes B4, C4, and D4; EMBP, eosinophil major basic protein; ECP, eosinophil cationic protein. Note that not all asthmatic subjects respond to cromolyn sodium or nedocromil sodium and that theophylline is only a second-line drug. Reproduced with permission from Rang, H. P., Dale, M. M., Ritter, J. M., and Gardner, P. (1995). "Pharmacology." Churchill-Livingstone, New York.

hibitors such as aspirin or indomethacin are known to delay the onset of labor. Administration of PG, often in the form of PGF2„, can produce side effects and should not be given to patients with a history of asthma. PGs are generally useful as abortifacients after the eighth week of pregnancy. In the second trimester, PGE2 and PGF2a can be given by the intrauterine route and other PGs can be given intramuscularly or vaginally to promote the termination of pregnancy.

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