Boq

LEUKOTRIENES Formed by 5-Lipoxygenase Pathway

FIGURE 16-2 Overview of enzymatic pathways giving rise to major prostaglandin relatives. Subscript number refers to the number of double bonds in the structure (most have equivalent structures with one double bond, not shown here). COX1 is constitutive cyclooxygenase; the conjugated leukotrienes are LTC4 and LTD4. a, in PGF2„ refers to the steric position of the C-9 substituent.

ho oh cooh cooh

Metabolites cooh oh ho oh Lipoxin B

Hydroxylation

Other hydroxylated PGs

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