Tsh

A Galactose

• N-Acetylglucosamine □ N-Acetylgalactosamine ■ N-Acetylneuraminic acid

FIGURE 5-9 Oligosaccharide chains of thyroid-stimulating hormone (TSH). Schematic representation of the typical oligosaccharide chains present on the TSH heterodimer and the free a-subunit. Glycosylated asparagine (Asp) and threonine (Thr) residues are indicated. Black and white circles, half-circles, and triangles represent the oligosaccharide chain residues as indicated in the key. Reproduced with permission from Sarapura, V. D., Samuels, M. H., and Ridgway, C. E., (1995). Thyroid-stimulating hormone. In "The Pituitary" (S. Melmed, ed.), pp. 187-229. Blackwell Science, Oxford.

Putative signal peptide (-131)

N-terminal fragment

AL and IL

0 0

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