Tissue location

Release stimulated by

Proposed function

Possible mode of action

Hypothalamus (see Chapter 3) Pancreatic D cells (see Chapter 7)

Stomach, duodenum, colon

Pancreas: glucose, arginine Hypothalamus: inhibit growth hormone release GI tract: after ingestion of a mixed meal, but SS-28 8> SS-14 Hypothalamus: inhibit release of growth hormone Pancreas: inhibit insulin and glucagon secretion GI tract: paracrine agent to inhibit gastrin release and acid secretion Interaction with specific membrane receptors, coupled to Gs proteins and adenylate cylase; there is evidence for separate receptors for SS-28 and SS-14


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