FIGURE 5-28 Structure of human IGF-I, IGF-II, and insulin (ins), with amino acid residues aligned to show the homologies identified by the boxed areas. Single-letter codes are used for amino acid residues. Note that in insulin the C peptide is removed, whereas in IGF-I and IGF-II the A and B chains (domains) remain connected by the C peptide. In addition, there are D domains. Modified and reproduced, with permission, from Sara, Y. R., and Hall, K. (1990). Insulin-like growth factors and their binding proteins. Physiol. Rev. 70,591. Reproduced with permission from Ganong, W. F. (1995). "Review of Medical Physiology," 17th edition. Appleton and Lange, Norwalk, CT.

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