Human GM-CSF 1 Intracellular

Ceil membrane -

^_^ Extracellular

100 amino acids

FIGURE 15-21 Diagram of selected members of the family of membrane receptors that participate in hematopoiesis. Schematic representations of the structures of all the known members of the family are shown. Horizontal bars represent conserved cysteine residues. The black boxes represent the conserved Trp-Ser-X-Trp-Ser (WSXWS) motif. The stippled areas shown the stretch of —210 amino acids within which the receptor homologies are contained. The immunoglobulin-like domain at the N-terminus of the IL-6 receptor is also indicated. Modified from Casman, D., Lyman, S. D., Idzerda, R. L., et al. (1990). A new cytokine receptor superfamily. Trends Biochem. S ci. 15, 265-270.

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