S

Enkephalins

Gq (cAMP |) G protein coupling to ion channel (?)

Closure of voltage-gated Ca2+ channels inhibiting transmitter release

Analgesia

(t

Not selective

Gq (cAMP J,)

Associated with glutamate-activated ion channels; site of action of psychotomimetic drugs, e.g., phencyclidine

Dysphoria

" Constructed, in part, from Ganong, W. F. (1995). "Review of Medical Physiology". Appleton and Lange, Norwalk.

" Constructed, in part, from Ganong, W. F. (1995). "Review of Medical Physiology". Appleton and Lange, Norwalk.

a-N-acetyl-/3-endorphin (1-27). This posttranslational processing is summarized in Figure 5-34.

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