FIGURE 10-30 Structure of RU-486 compared to progesterone, Cortisol and testosterone whose receptors are affected by RU-486.
Protein metabolism Thinning of skin Reddish striae
Loss of bone matrix and demineralization
Poor wound healing
Muscle wasting and weakness
Capillary fragility and bruising Impaired growth (children) Carbohydrate metabolism Abnormal glucose tolerance curve Overt diabetes mellitus
Centripetal fat distribution Moon face
Sodium retention, potassium loss
Eosinopenia, lymphopenia Polymorphonuclear leukocytosis Erythrocytosis
Hypercalciuria and renal calculi
Impaired immunological tolerance a Cushing's syndrome is most often caused iat-rogenically by administration of large amounts of glucocorticoids.
Reproduced from Ezrin, C., Godden, j. O., Volpe, R., and Wilson, R. (eds.) (1973). "Systematic Endocrinology," p. 171. Harper & Row, New York.
FIGURE 10-31 Bilateral diffuse adrenocortical hyperplasia with moderate folding and segmentation of the surface in a 5-year-old girl with congenital adrenogenital syndrome. The bean-shaped organ below is the kidney and the arrow points to the hyperplastic adrenal glands. Reproduced from Labhart, A. (ed.,) (1976). "Clinical Endocrinology," p. 362. Springer-Verlag, Berlin and New York.
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