Ru 486

FIGURE 10-30 Structure of RU-486 compared to progesterone, Cortisol and testosterone whose receptors are affected by RU-486.

Protein metabolism Thinning of skin Reddish striae

Loss of bone matrix and demineralization

Poor wound healing

Muscle wasting and weakness

Capillary fragility and bruising Impaired growth (children) Carbohydrate metabolism Abnormal glucose tolerance curve Overt diabetes mellitus

Lipid metabolism

Centripetal fat distribution Moon face

Electrolyte balance

Sodium retention, potassium loss

Hypertension

Hypervolemia

Hematopoietic effects

Eosinopenia, lymphopenia Polymorphonuclear leukocytosis Erythrocytosis

General effects

Hypercalciuria and renal calculi

Gastric ulceration

Psychosis

Impaired immunological tolerance a Cushing's syndrome is most often caused iat-rogenically by administration of large amounts of glucocorticoids.

Reproduced from Ezrin, C., Godden, j. O., Volpe, R., and Wilson, R. (eds.) (1973). "Systematic Endocrinology," p. 171. Harper & Row, New York.

FIGURE 10-31 Bilateral diffuse adrenocortical hyperplasia with moderate folding and segmentation of the surface in a 5-year-old girl with congenital adrenogenital syndrome. The bean-shaped organ below is the kidney and the arrow points to the hyperplastic adrenal glands. Reproduced from Labhart, A. (ed.,) (1976). "Clinical Endocrinology," p. 362. Springer-Verlag, Berlin and New York.

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