Prostaglandins

I. INTRODUCTION

A. Background

B. Structural Classes of Prostaglandin (PG) Relatives

C. Classification of PGs

D. General Aspects of PGs

II. CHEMISTRY

A. Conformation of PGs and Thromboxanes (TX)

B. Phospholipase A2 Enzymes

III. BIOCHEMISTRY

A. Biosynthesis

B. Metabolism

C. Binding Proteins and Receptors

IV. BIOLOGICAL ACTIONS

A. PGF2a as an Agent for Therapeutic Abortion

B. Pancreas

C. Ectopic Bone Resorption

D. Autonomic Nervous System

E. PGI2 in Fibroblasts

F. PGs and the Pain Mechanism

G. Antihypertensive Renal Effects

H. The Platelet System

V. LEUKOTRIENES (LTs)

A. Background

B. LT and Asthma

VI. CLINICAL ASPECTS

A. Abortion

B. Erectile Dysfunction

C. Gastroduodenal Ulceration

D. Myocardial Infarction

E. Implantation of Embryo References

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