" In humans, a-MSH is probably released from pars intermedia-like cells under the positive action of dopamine, not CRH. In these cells, the ACTH moiety is further broken down to a-MSH and CLIP, and these hormones are secreted together with /3-endorphin (breakdown product of /8-lipotropin).

h These activities may derive from the neurointermediate lobe (at least in higher animals). PRF (a polypeptide of MW less than 5000) does not appear to be oxytocin, AVP, or /3-END); however, PIF could be related to oxytocin.

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