Posterior Pituitary Hormones

I. INTRODUCTION

II. ANATOMY AND DEVELOPMENT OF THE POSTERIOR PITUITARY

III. CHEMISTRY

A. Structures of Active and Substituted Posterior Pituitary Hormones

B. Interaction of Posterior Pituitary Hormones with Active Sites of Neurophysins

IV. BIOCHEMISTRY

A. Formation and Neurosecretion of Posterior Pituitary Hormones

V. BIOLOGICAL AND MOLECULAR ACTIONS

A. Role of VP (Antidiuretic Hormone) in the Regulation of Body Fluids

B. The VP Target: The Kidney Distal Tubule

C. Mechanism of Action of VP in the Kidney Distal Tubule

D. Nature of Kidney VP-Sensitive Adenylate Cyclase

E. Effects of VP on the Liver

F. VP and ACTH Release

G. Behavioral Effects of VP

H. Overview of Regulation of Oxytocin Secretion from the Posterior Pituitary

I. Mechanism of Action of OT J. The OT Receptor

K. Degradation of Posterior Pituitary Hormones

VI. CLINICAL ASPECTS References

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