FIGURE 15-14 Intracellular signaling mechanisms activated by endothelins. Activation of PKC is known to stimulate the opening of the Ca2+ channel. Activation of phospholipase C is central to the generation of cellular responses to ET. An increase in the concentration of intracellular free Ca2+ is indispensable to eliciting responses to the endothelins. ET also stimulates a plasma membrane Ca2+ channel and induces an increase in the influx of extracellular Ca2+. Since endothelins have been shown to open a nonselective cation channel or chloride channel and to induce depolarization (dep), it is likely that the Ca2+ channel may also be opened by depolarization. Endothelins also open a K+ channel and induce hyperpolarization (hyperp). This inhibits the Ca2+ channel. An increase in the concentration of [Ca2+]; inhibits Ca2+ influx. Activation of PKC is known to stimulate the opening of the Ca2+ channel. Abbreviations: ETr, ET receptor; G, G protein; PLC, phospholipase C; PLD, phospholipase D; IP3, inositol triphosphate; DG, diaclyglycerol; PKC, protein kinase C; [Ca2+]i, concentration of intracellular free Ca2+; CaCh, calcium channel; CICh, chloride channel; NsCh, nonselective cation channel; KCh, K+ channel. Inositol trisphosphate stimulates the intracellular calcium pool to release Ca2+. Modifed with permission from Masaki, T. (1993). Endothelins: Homeo-static and compensatory actions in the circulatory and endocrine systems. Endocri. Rev. 14, 256-268.


Cure Tennis Elbow Without Surgery

Cure Tennis Elbow Without Surgery

Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.

Get My Free Ebook

Post a comment