O

11-Dehydrocorticosterone

CH2OH

11-Dehydrocorticosterone

CH2OH

3a,21-Dihydroxy-5(3-pregnane-11, 20-dione

3a,21-Dihydroxy-5(3-pregnane-11, 20-dione

3a,ll/3,21-Trihydroxy-5/3-pregnan-20-one

3a,110,21-TRIHYDROXY-5a-PREGNAN-20-QNE

FIGURE 10-18 Metabolism of corticosterone (A) and Cortisol (B). Reproduced from Schulster, D., Burstein, S., and Cooke, B. A., (1976). "Molecular Endocrinology of the Steroid Hormones," pp. 156-157. Wiley, New York, by copyright permission.

action (see Chapter 16 for further information). The glucocorticoids have also been shown to exert antiinflammatory action at the level of the IL-6 promoter. Since IL-6 is an inflammatory cytokine, its inhibition would reduce the inflammatory process (Figure 10-21).

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